Jurnal Kesehatan Indonesia (Jurkessia)

Jambu Biji Merah (Psidium Guajava Lynn) Terhadap Kadar Asam Urat Darah Pada Ayam Broiler Hiperurikemik

Rissa Saputri1*, Lily Arsanti Lestari2, Nurhidayat3

Abstract

Gout is one of arthritis type relating to hyperuricemic condition. Some researches in west countries indicated that gout prevalence and incidence tend to increase in past years. In other side, the used of drug has side effect of increasing renal and cardiovascular disease. Red guava (Psidium guajava Lynn) potential to be used for gout therapy. Red guava contains antioxidant having effect of inhibiting xantin oxidase activity. To study effect of red guava juice on blood uric acid level of hyperuricemic chicken Twenty five male broiler chickens as experimental animal were raised since 2 days old. When they were 18 days, they were put into battery cage and divided into 5 groups. Standart feed and drink were administrated ad libitum. All group were conditioned hyperuricemic with high purine diet. After hyperuricemic condition was reached, group 1, 2, and 3 were administrated with red guava juice with 5, 10, and 20 ml/kgBW dosages. Group 4 was positive control group (20 mg/kgBW allopurinol), while group 5 was negative control group (hyperuricemic condition, without administration of red guava juice or allopurinol). Blood sample was taken to examine uric acid level at day-0 (before treatment), 8 (after high purine diet administration), and 17 (after red guava juice administration). Results of examination were analyzed statistically using one-way ANOVA followed with post hoc LSD with 95% confidential interval (p=0,05). The results indicated that administration of red guava juice group underwent significant decrease in post-test blood uric acid level compared with pre-test blood uric acid level. red guava juice can decrease uric acid level in the blood of hyperuricemic broiler chicken.

Keywords : red guava, hyperuricemic, broiler chickens, allopurinol

(Jurkessia, Vol. I, No. 1,  hal 1 – 7)

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